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COMBIOLOGICAL TREATMENT OFFERS NEW HOPE TO CHILDREN BATTLING DEAD BRAIN CANCER

COMBIOLOGICAL TREATMENT OFFERS NEW HOPE TO CHILDREN BATTLING DEAD BRAIN CANCERThis drug combination uncovered what is known as "don't eat me" in a new study
COMBIOLOGICAL TREATMENT OFFERS NEW HOPE TO CHILDREN BATTLING DEAD BRAIN CANCER


In a groundbreaking discovery, researchers at the University of Colorado Anschutz Medical Campus have uncovered a promising drug combination that could improve the prognosis of children who have MYC-amplified medulloblastoma, a type of breast cancer that is a particularly deadly brain.

These studies were carried out in cooperation with the German Cancer Consortium (DKTK) and the University Hospital Düsseldorf.

These tumors are particularly aggressive because of an oncogene called MYC, making them more likely to come back and spread to "other parts of the brain and spine," according to lead author Siddharth Mitra.

Currently, "the 5-year survival rate for this type of cancer is less than 45%."

"We wanted to find better treatment options for these children."

Mitra and his team found that the combination of two drugs that have already successfully passed phase I safety trials in other types of solid tumors had a significant effect on MYC-amplified medulloblastoma.

Scientists, using the epigenetic drug tacedynalin, discovered that MYC not only causes tumors to grow but also makes them invisible to cells of the immune system.

So you could remove the "Don't eat me" barriers in the immune system that normally prevent macrophages from eating the tumor.

They thus made the tumor more attractive to the immune system.

When we used Takedinelin to unblock these pathways and then added anti-CD47, a drug that turns macrophages into super eaters, the tumor became extremely palatable to the macrophages, resulting in them eating the unblocked tumor, Mitra said.

"You're basically taming the body's immune system by giving it a boost, just like the medical version of PacMan."

With "Takedineline to unleash these signaling pathways" and then "anti-CD47 to administer, "a drug that increases the ability of macrophages to engulf tumors made the tumor highly attractive to cells of the immune system and encouraged them to attack and destroy it, according to the lead author.

"It uses in the Essentially the body's immune system and gives it a quick boost, just like the medical version of PacMan Immune evasion pathways are first attacked in this type of deadly brain tumor.

Traditional cancer treatments in adults are not effective in children because their bodies are still growing and their healthy cells are dividing rapidly, Mitra said.

"This combination of drugs" has the potential to not only reduce the negative side effects of "conventional cancer treatments" in children but also to increase the survival rate of patients "who have been diagnosed with MYC-amplified medulloblastoma".

The next step, he says, would be clinical Studies to test the immediate and long-term benefits of treatment.

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